Levy was born in Milwaukee, Wisconsin, where he attended Vincent High School and was a letterman in football, basketball, and track.

As a senior, he recorded 84 tackles, five sacks, and four forced fumbles as a linebacker and 12 receptions for 260 yards and three touchdowns as a tight end.

[1][2] Subsequent to the Penn State child sex abuse scandal, Levy now calls that incident "my proudest moment in college".

In Week 16, against the Miami Dolphins, Levy returned an interception of Chad Henne 30 yards for the game-winning touchdown in a 34–27 win.

In April 2016, DeAndre wrote a column for The Players' Tribune encouraging men and especially professional athletes to take leadership in sexual assault prevention.

[16] The couple commissioned a mural in Eastern Market in 2017 to encourage survivors of sexual assault and harassment to open up about their stories.

[17][18] In 2020, Levy appeared as a guest on Jada Pinkett Smith's Red Table Talk, along with Amber Rose and Rumer Willis to discuss sexual consent.