She also performed in The Cradle Will Rock, The Merry Wives of Windsor, and Pericles, and toured in The Bat, Grease and I Oughta Be in Pictures.

In 1988, she went to star with Scott Bakula and Patricia Richardson in the one season of the CBS sitcom Eisenhower and Lutz.

[1][2] In 1993, Matthews landed a female leading role opposite Harry Anderson in the CBS sitcom Dave's World; the series ran to 1997.

Matthews guest-starred in a number of television series, including Murphy Brown, From the Earth to the Moon, Diagnosis: Murder, Strong Medicine, Cold Case, Nip/Tuck, Castle and well as recurred on The Shield and Saving Grace.

In 2001, she joined the cast of ABC soap opera General Hospital playing Janine Matthews.