As part of its mission and vision, DePaul Prep teaches the charism of St. Vincent de Paul, encouraging its students to serve those who live on the margins of society.

In 2012, a group of trustees and administrators of DePaul University was asked by the Archdiocese of Chicago and the priests and brothers of the Congregation of the Resurrection (“Resurrectionists”) to assist Gordon Tech High School.

In July 2019, in response to a rapidly growing enrollment, DePaul College Prep's Board of Directors acquired a new 17-acre campus and modern school buildings at 3300 N. Campbell, Chicago, Illinois.

The 17 acre campus includes the 178,000 square foot Mary A. Dempsey Academic Center, comprising 62 modern classrooms, 2 student dining halls, 4 maker spaces, 10 state-of-the-art science labs, Black Box Theatre, strength training and weight room, library, chapel, and 2 student gathering spaces.

Students are able to choose from a wide range of course offerings, including College Prep, Honors, Advanced Placement (AP), and International Baccalaureate (IB) classes.