The district consists mostly of Depauw Avenue from Vincennes Street in the west to Aebersold Drive to the east, and includes portions of the 1200 block of Beechwood Avenue and two residences on Vance Street.

New Albany High School is located on the southern edge of the district.

Washington C. DePauw, a wealthy New Albany banker, was the original owner of the land.

The district began as a neighborhood for upper-class residents, and quickly became a preferred place to live in New Albany.

7.1, 8.49 In 1994 an architectural study determined that DePauw Avenue could eventually achieve National Register status.