The company has offices in Boston, Chicago, Dallas-Fort Worth, Foxborough, Houston, Las Vegas, Miami, New Haven, New York City, San Francisco, London, Medellín, Abu Dhabi, and Dubai.

[12] DeSimone was nominated and received a Diamond Award for Structural Systems from the American Council of Engineering Companies in 2016 for their work on 170 Amsterdam.

Like with The Grove at Grand Bay project, placing the buildings support systems on the exterior allows for increased space inside and reduces the amount of materials used.

The twisting element of the buildings has a total rotation of 38 degrees, and provides panoramic views of the Biscayne Bay and the Miami skyline.

The horizontal component of the gravity load in the columns is resolved in the slabs by transferring it to the interior core shear walls, which are the only consistently vertical structural elements in the building.

[18] DeSimone was nominated and received a Platinum Award for Structural Systems from the American Council of Engineering Companies in 2016 for their work on The Grove at Grand Bay[13] DeSimone has served as structural engineer for many skyscrapers and is currently working on a supertall building, 125 Greenwich Street designed by Rafael Viñoly which tops out at over 1,000 feet.

[21] DeSimone has worked on projects with many of the world's most renowned architects and architectural firms including Zaha Hadid,[22] Bjarke Ingels,[23] Richard Meier,[24] Robert A.M. Stern,[25] Foster and Partners, Rafael Viñoly, Rem Koolhas,[26] Office for Metropolitan Architecture (OMA),[26] Skidmore, Owings & Merrill (SOM), Kohn Pedersen Fox (KPF),[25] Arquitectonica,[27] and SLCE.

[35][36] The Houston based firm was previously owned by Ryan Binkley's Generational Equity and specialized in aviation, education, commercial, sports and healthcare facilities.

[43] Part of the firm's larger expansion into Florida, and southeastern market, Fourzero was founded in 2013 and led by 20 year industry veteran Federico Balestrazzi, who had an extensive record of working with DeSimone's Miami office.

[43] On January 6, 2023, DeSimone Consulting Engineering announced they had acquired Dowco, a Langley, British Columbia, based steel detailer for an undisclosed amount.

[44][45][46][47] Dowco was founded in June 1970 by Hugh Dobbie, Joe Ord and Jack Wilson (whose last initials spell DOW).

[47][49][50] On 1 August 2023, DeSimone acquired DP Squared, a civil engineering firm established by Darren and Deborah Paine in 2004.

[10] On October 17, 2023, continuing the firm's push to establish themselves in the United Kingdom, DeSimone acquired the Cheshire based construction consultancy Decipher.