The DeWitt Commercial Historic District encompasses part of the historic downtown of De Witt, Arkansas, the seat of the southern district of Arkansas County.

It consists of roughly six square blocks, focused on Courthouse Square, location of the Southern District Courthouse.

The district includes 54 historically significant buildings, 32 of which face Courthouse Square.

The oldest buildings in the district lie just north of Courthouse Square, either facing the square or in North Main or Gibson Streets.

[2] The district was listed on the National Register of Historic Places in 2010.