The university was established on July 18, 1977, as a private, nonsectarian tertiary school named General Emilio Aguinaldo College-Cavite and managed by the Yaman Lahi Foundation.

In 1987, ownership and management were transferred to Frère (St.) Bénilde Romançon Educational Foundation Inc., a sister corporation of De La Salle University-Manila.

As part of DLSU-D's aim for cultural development, and maintaining its Spanish-period-inspired motif, the three structures in the Museum Complex were officially named the Br.

Other varsity sports include track and field, taekwondo, judo, aikido, table tennis, badminton, chess and football.

Their basketball playing style has given them marginal success that includes a runner-up finish in the UCAA against their former namesake Emilio Aguinaldo College in 2005.

[7] The Lasallian "Signum Fidei" Sign of Faith Star is a 350-year-old international symbol of the Christian Brothers of the De La Salle Schools that represents their religious vocation of quality God-centered, Christian-values-based education in 1,500 Lasallian institutions with 70 Universities and Colleges that are globally established by Saint La Salle's Christian Brothers in 82 countries.

[citation needed] The Signum Fidei Lasallian was inspired by the Nativity Christmas Star from Bethlehem that symbolized Saint La Salle's mission of Teaching Minds, Touching Hearts, and Transforming Lives of the very poor.

Around 25,000 Lasallians and supporters of La Salle became part of the star and contributed to reaching the target of raising P2.5 million for the scholarship fund.

Founded and established in 2016, the publication serves as a medium (through print, online, and radio) for students to be aware of all current events and latest updates happening around the senior high school community.

"[10] De La Salle University-Dasmariñas (DLSU-D) had broken records with its human formation of the Lasallian Signum Fidei Star and a coin mural of the school logo.

To commemorate the 300th feast day of its founder, thousands of people held color-coded umbrellas to form the largest image of Saint Jean-Baptiste de La Salle at the DLSU-D Track Oval on Sunday, April 7, 2019.

About 6,000 students, employees, and stakeholders of DLSU-D participated in the fundraising event dubbed "Animosaic 2: Humans of St La Salle."

The fundraising event is dedicated to all the scholars and aspiring scholars of DLSU-D. Seeking to beat the record set by China after it formed a giant human smiley with 3,099 participants in 2016, Lasallians made their own bid for the record with some 6,000 Lasallians forming the image of Saint Jean-Baptiste de La Salle, the university name as well as the #300LaSalle which signifies the 300th death anniversary of the Father Founder.