De Pere (/di ˈpɪər/ dee-PEER)[7] is a city in Brown County, Wisconsin, United States.

When the first European, Jean Nicolet, visited the place in 1634–35, De Pere was the site of a polyglot settlement of several thousand attracted by the fishing at the first rapids of the Fox River.

[9] In 1671, French Jesuit explorer Père Claude-Jean Allouez founded the St. Francis Xavier Mission at the last set of rapids on the Fox River before it enters The Bay of Green Bay.

[10] The present city of De Pere had its beginnings in 1836, when John Penn Arndt and Charles Tullar incorporated the De Pere Hydraulic Company and drew up the first plat of the town.

[12] Politically, under the first township plan for Brown County, the area that is now the city of De Pere fell on the boundary between the town of Howard (which comprised much of the area west of the Fox River) and the town of "Mason", which comprised roughly the southern half of the county.

In 1838, the area was first formally established by the territorial government as a separate township entity.

At that time it was named the town of "Wilcox", for Randall Wilcox, who was then president of the De Pere Hydraulic Company, and it comprised most of the area of the current city of De Pere as well as the area that is now the town of Ledgeview, Wisconsin.

[14] St. Norbert College, which abuts the banks of the Fox River on the city's west side near the Claude Allouez Bridge, was founded by Norbertine Abbot Pennings in 1898.

De Pere has several areas on the National Register of Historic Places.

Large homes line Broadway, Ridgeway Blvd., Morris, Fulton, Franklin, Cass, Front, and Wisconsin Streets near the Fox River.

[15] The De Pere Lock and Dam Historic District (#93001331) was added in 1993.

St. Norbert Abbey is the mother canonry of the Premonstratensian Order in the United States.

André Jacque represents De Pere in the Wisconsin State Senate, while Shae Sortwell represents De Pere in the Wisconsin State Assembly.

De Pere has a mayor-council form of government with a full-time city administrator.

Syble Hopp is a school for children ages 3–21 years old who have cognitive and other developmental disabilities.

The Fox River is navigable for boat and canoe traffic with the exception of a dam.