DePeyster is a town in St. Lawrence County, New York, United States.

Thus, a correspondence was opened with landowner Frederic de Peyster, whose name was ultimately chosen for the new town.

[3] Newton Martin Curtis, Medal of Honor recipient - born in the town and was a postmaster, brigadier general, and customs inspector.

Patty Ritchie, New York State Senator - raised in DePeyster.

New York State Route 812 crosses the northern part of the town.

The racial makeup of the town was 98.61% White, 1.07% African American, 0.11% Pacific Islander, and 0.21% from two or more races.