[1] The gallery's contemporary art program exhibits and promotes emerging artists from Asia,[2] and its advisory focuses on 19th and 20th century master paintings and sculptures.

[1] DE SARTHE exhibits works that reflect upon the complex and permeating implications of 21st century technology, representing creative practices that navigate and traverse the virtual realms colliding into reality today.

[18] The gallery also works with artists such as Dong Jinling,[19] Double Fly Art Center,[20] Jung Jin,[21] Wang Jiajia,[22] Xinyan Zhang,[23] and more.

[24] (curated by Forever & Today) The Caveman, The Literati, The Iconoclast [29] Additionally, the gallery works in the secondary market for European and Asian modernist artists such as Zao Wou-ki, Chu Teh-Chun, Pablo Picasso, Mark Rothko, Joan Miro, Alexander Calder, Gerhard Richter, Andy Warhol, Yves Klein, Auguste Rodin, and Atsuko Tanaka, among others.

The exhibition was curated by Jonas Stampe and Xiao Ge, featuring almost 180 works that the artist made across his career including paintings, drawings, sculptures, photography, sound, film, and performances.

[41] The presentation was well-received by press and was covered by local as well as international media including ArtAsiaPacific,[41] Artnet,[39] Tatler Asia,[42] CNN Style,[43] TimeOut,[44] High Snobiety,[45] RTHK,[46] China Daily,[47] Singtao,[48] CNBC,[49] and more.

[50] In 2021, the gallery presented a large-scale kinetic installation by its then represented artist Andrew Luk in the Encounters sector of Art Basel Hong Kong.

[57] In 2019, the gallery organized a live performance by French artist Bernar Venet in Hong Kong in collaboration with Sotheby's and amfAR.

[58] In 2016, the gallery presented a solo exhibition by American artist Robert Rauschenberg at its Central space, featuring six significant works from different series spanning from 1968-2005.

[66] The exhibition was organized in a collaboration between the gallery's founder Pascal de Sarthe and Morgan Art Foundation Ltd.[67] The show was a broad survey of Indiana's career, featuring over 80 works comprising sculptures, paintings, and serigraphs.