De Witt is a city in Carroll County, Missouri, United States.

[6] According to the United States Census Bureau, the city has a total area of 0.24 square miles (0.62 km2), all land.

The racial makeup of the city was 90.3% White, 5.6% African American, and 4.0% from two or more races.

22.4% of all households were made up of individuals, and 6.1% had someone living alone who was 65 years of age or older.

14.3% of all households were made up of individuals, and 4.8% had someone living alone who was 65 years of age or older.

There were no families and 6.9% of the population living below the poverty line, including no under eighteens and none of those over 64.