De la Gauchetiere Street (officially in French: rue De La Gauchetière) is a street in Montreal, Quebec, Canada, running through downtown Montreal, the International District and Chinatown.

In Chinatown, it takes the form of a pedestrian zone, between Saint Laurent Boulevard and Jeanne Mance Street.

The street runs through downtown Montreal and is home to such landmarks as Place Bonaventure, the 1000 de la Gauchetière skyscraper and the Château Champlain.

De la Gauchetiere also forms the southern edge of Place du Canada.

It is named after the landowner Joseph-Daniel Migeon, also called the Sieur de la Gauchetière in honour of his mother, Catherine Gauchet.