The story explores the characters' pre X-Men relationship, and is another in a series of limited print runs where Deadpool battles another character from the Marvel Universe.

[1] The series' creation was influenced by the release of the Deadpool film, which was then enjoying box office and critical success, a Gambit film that was in development, and of the then recently-released Batman v Superman: Dawn of Justice, of which the title of the series is in reference to.

"[3] Blacker mentioned that they had submitted a proposal to expand the miniseries into a full Deadpool v. Gambit ongoing series, which he hoped would be approved in early 2017,[3] although it was ultimately rejected, leaving Deadpool V Gambit: The "V" is for "Vs." a simple miniseries.

[5][6] Mark Hassenfratz of ComicsVerse said that he had low expectations of the series due to Deadpool's "overexposure" after the release of his solo movie, but indicated that he enjoyed the first issue "way more" than he thought he would.

[7] John McCubbin of Snap Pow called the first issue "strange and muddled" and lacking focus, but also said he believed the first issue "showed some promise, even if it came during the last page.