To date, Arsene's professional career has been almost solely in the American Hockey League, where he has played twelve seasons.

He spent six of those seasons (from 2003–04 to 2008–09) with the Hershey Bears, winning the league's championship Calder Cup twice in that tenure, and earning the fond nickname "Mayor of Chocolatetown."

Following his second Calder Cup, Arsene chose to sign the two-way contract with the Edmonton Oilers in the hope of earning some playing time in the NHL on July 16, 2009.

On August 11, 2010, Arsene signed as a free agent to a one-year, two-way contract with the St. Louis Blues.

[5] In his final professional season, Arsene returned home, signing a one-year contract with the Abbotsford Heat for the 2013–14 campaign.