Demopoulos was born in Philadelphia, Pennsylvania, and graduated from West Chester State in 1977 with a degree in comprehensive social sciences.
[3] During that span, the Owls became a national basketball powerhouse, amassing a 393–151 (72.2%) record and making it to the NCAA Tournament 16 times and to the Elite Eight on four occasions.
[1] For the 2000–01 college season, Demopoulos served as head coach of the Kansas City Roos men's basketball team.
In April 2015, Demopoulos was hired by Australian NBL club Melbourne United to be head coach on a two-year deal.
[12] On January 19, 2022, Demopoulos was announced as the new head coach of the Saskatchewan Rattlers of the Canadian Elite Basketball League (CEBL).