In 1984, Melchiondo met Aaron Freeman in a junior high school typing class, in their hometown of New Hope, Pennsylvania.

[3] In 1991, Melchiondo formed the punk rock duo Moistboyz with Guy Heller.

[5] Melchiondo made contributions to two projects by his friend Josh Homme: The Desert Sessions and Queens of the Stone Age.

In 2009 Melchiondo received his captain's license and regularly leads fishing trips off the Jersey Shore as Mickey's Guide Service.

[14] Melchiondo's second solo album under The Dean Ween Group moniker, rock2, was released on March 16, 2018.