Around 1333 the Lords of Man refortified St Patrick's Isle and occupied the church as a fortress.

The present building was constructed in 1879–84 to replace St Peter's Church in Peel's market place.

[15] In 2016, following the mass shooting at Pulse, a nightclub in Orlando, Florida, the cathedral displayed a rainbow flag at a candlelit vigil for the victims to "show solidarity with the LGBT community.

"[16] As of 30 December 2020:[17] Bishop Hildesley established a children's choir at his private chapel at Bishopscourt as early as 1755.

At the opening of Peel New Church in 1884, Ms ML Wood ARCO was appointed the first organist and directed a large choir.

It is planned that the pipe organ will be rebuilt, re-ordered and significantly enlarged over the next five years, to meet the demands of the cathedral's developing choral programme.