[5] From Peter Street southwards the eastern side was dominated by the viaducts of the Great Northern and Manchester South Junction Railways, whilst the Rochdale Canal crossed below Deansgate to connect with the other waterways beyond.

In the late 20th century Deansgate was home to the head office of the Manchester Evening News newspaper, now replaced by part of the Spinningfields development.

[6] A statue of Oliver Cromwell at the northern corner commemorated Manchester's support for Parliament in the English Civil War.

At 820 square metres (8,800 sq ft), able to accommodate 1,700 customers, and employing 60 staff, it has been listed in The Guinness Book of Records as the largest public house in Britain.

Other buildings in the Deansgate area include the Royal Bank of Scotland, the Beetham Tower and the redeveloped Great Northern Warehouse.

Today, the main transport links on Deansgate are the National Rail and Manchester Metrolink stations and a number of bus routes, including the Metroshuttle services.

Deansgate Station was opened at Knott Mill on 20 July 1849 by the Manchester, South Junction and Altrincham Railway.

In the first half of the 20th century, Deansgate was a route for trams operated by Manchester Corporation Tramways, and subsequently carried numerous bus services.

In 2019, Extinction Rebellion occupied a section of the road from St Mary’s Gate to John Dalton Street for four days, with tents and organised talks on climate change, sustainable living and resistance.

[15] In August 2011, thousands packed the street as Jenson Button drove a McLaren MP4-23 along Deansgate as part of the Vodafone Vip Live Manchester festival.