[1] According to PubMed,[2] this database has been cited by seven peer-reviewed articles to date because of its extensive and specific information on the death domains and their PPI summaries.
[11] Protein modules containing the CARD domain are associated with apoptosis, through the regulation of caspases that they are interacting with, as well in inflammation processes through its participation in NF-kappaB signaling pathways.
[7] Deathdomain.org was initially created by Kwon et al. (2012) to stimulate further research into the death domain superfamily mediated signaling pathway.
Their database is manually curated and focuses on providing detailed information on the death domain superfamily and its protein-protein interactions.
Kwon and his team started by researching, compiling and curating 295 published peer-reviewed studies that focused on PPI modules and their associated death domains.
The authors for the site started by finding synonyms for the 99 death domain superfamily proteins from UniProtKB[16] and Entrez Gene.
The authors were able to find and manually curate 295 peer-reviewed articles that discussed 175 PPI pairs among 99 DD superfamily proteins.
These numbers have increased since the original publication to 311 peer-reviewed papers discussing 181 PPI pairs among 99 DD superfamily proteins.
[22] In most cases, for each PPI, users can learn more about them by clicking the PubMed ID, giving details including the title, abstract, authors, interactions mentioned in the article, and a link to the publication.
The latter conveniently allows users to obtain the amino acid sequences and domain boundaries from UniProtKB/Swiss-Prot and UniProtKB/TrEMBL databases in either embl, genbank or fasta format.
They can also access more information on similar databases (Uniprot, DIP, STRING, KEGG, IntAct, and MINT) by clicking the appropriate identifier number.