Fashion model Valentina agrees to help her journalist boyfriend Gio Baldi research the effects of a new hallucinogen similar to LSD.

La morte accarezza a mezzanotte marks the third collaboration between director Luciano Ercoli and screenwriter Ernesto Gastaldi, who had previously worked together on 1971's La morte cammina con i tacchi alti and 1970's Le foto proibite di una signora per bene.

[2] Ercoli's wife Nieves Navarro, credited here as Susan Scott, featured in several of his other films, often in similar roles as "tough, independent" women.

[3] The director's preference for this type of character has been noted as being inspired by fumetti, a form of Italian photonovel often featuring such roles.

[8] Writing for AllMovie, Robert Firsching gave the film one star out of five, calling it "laughably camp fun".