Set within the city of Glasgow, the novel follows divorcee teacher Charlie Bain's journey into hedonism and sex addiction.

Death of a Ladies' Man largely focuses upon hedonism, ageing, lust, compromise and feminism.

Regarding the recurring theme of feminism, Bissett noted, "You never write with a specific 'audience' in mind, but it does seem that women have reacted to the book more enthusiastically than men.

And I can see the thematic connections: Charlie Bain and Patrick Bateman, to a certain extent, inhabit similar worlds on either side of the Atlantic.

"[4] Whilst researching the novel, Bissett attended a party alongside Neil Strauss, author of The Game: Penetrating the Secret Society of Pickup Artists (2005), and other members of Glasgow's seduction community.

Regarding this event, Bissett noted, "That idea that sincerity becomes impossible, that all you have is a series of masks and you say whatever needs to be said, you use whatever tactic is required in order to get the target relaxed.

"[1] The novel is set within the city of Glasgow, making references to a number of locations including, Ashton Lane, The 13th Note Café, ABC, Byres Road, Nice N' Sleazy's, and many others.

I did feel I had a big Glaswegian beast seething around in there that wanted to come out in the strange, alien, beautiful, fucked-up way it did in [Death of a Ladies' Man].

"[2] Death of a Ladies' Man refers to many Scottish indie rock artists, including:[5] Idlewild, Malcolm Middleton, Frightened Rabbit, Zoey Van Goey, The Twilight Sad, Sons and Daughters and Y'all Is Fantasy Island.