As a sequel to Murder on the Orient Express (2017) and the second instalment of the Hercule Poirot film series, it was produced by Branagh, Ridley Scott, Judy Hofflund, and Kevin J. Walsh.

It stars an ensemble cast with Branagh and Tom Bateman reprising their roles as Hercule Poirot and Bouc, respectively, alongside Annette Bening, Russell Brand, Ali Fazal, Dawn French, Gal Gadot, Armie Hammer, Rose Leslie, Emma Mackey, Sophie Okonedo, Jennifer Saunders, and Letitia Wright.

A sequel, titled A Haunting in Venice, an adaptation of Hallowe'en Party, was released on September 15, 2023, with Branagh once again directing and starring as Poirot.

The film opens in Belgium at the Yser Bridge on October 31, 1914, in the front lines of World War I. Hercule Poirot's captain has been given a mission that is certain death for all his men.

He notices Jacqueline "Jackie" de Bellefort introducing her fiancé, Simon Doyle, to her childhood friend, heiress Linnet Ridgeway.

Six weeks later, in Egypt, Poirot encounters his friend, Bouc, with his mother, Euphemia, and the trio attend the wedding of Linnet and Simon.

After a boulder falls off a column and nearly crushes Linnet and Simon, the guests return to the Karnak to discover Jackie has boarded.

He found Linnet dead and stole her necklace to gain financial freedom from his mother, but panicked and put it in Euphemia's belongings.

While Jackie distracted Bouc and Rosalie, Simon killed Linnet, returned to the saloon, and shot his own leg, muffled by the scarf.

As a final clue, Poirot reveals that the handkerchief used in the fake shooting, recovered along with the gun, had faded to pink instead of brown, proving the stains were not blood.

[10] In October 2018, Armie Hammer joined the cast, and Tom Bateman was confirmed to reprise his role as Bouc for the film.

[16] Ali Fazal, Dawn French, Rose Leslie, Emma Mackey, Sophie Okonedo and Jennifer Saunders were added in September, with Comer not being involved.

[36] It was then pushed back two weeks to October 23, and again to December 18, in response to the domestic box office underperformance of Tenet during the COVID-19 pandemic.

Deadline Hollywood said Disney's marketing campaign was "anchored on a socially media quiet Gadot, who was more active during Red Notice.

[2] In the United States and Canada, Death on the Nile was released alongside Marry Me and Blacklight, and was projected to gross $11–17 million from 3,280 theaters in its opening weekend.

The website's consensus reads: "Old-fashioned to a fault, the solidly entertaining Death on the Nile is enlivened by its all-star cast and director-star Kenneth Branagh's obvious affection for the material.

[41] David Rooney of The Hollywood Reporter wrote: "For some of us who look back with affection on John Guillermin's lush 1978 screen version, there's a nagging feeling throughout that Branagh, while hitting the marks of storytelling and design, has drained some of the fun out of it.

"[66] Edward Porter of The Times gave the film three out of five stars, saying that its "gaudy style — combined with the melodrama of the script's modified take on Christie's plot — remains diverting even if some of the supposedly Egyptian backdrops look phoney.

"[67] Sandra Hall of The Sydney Morning Herald gave the film four out of five stars, writing: "While the gamble Branagh takes in disinterring Poirot's long-neglected sensitive side may be regarded as sacrilege by some, I think it works.

"[68] Wendy Ide of The Observer gave the film two out of five stars, writing: "The camera whirls giddily, dizzy from the sparkle and spectacle, but not quite able to conceal the fact that this is an empty bauble of a movie.

"[69] David Fear of Rolling Stone wrote that the film "has its joys and flaws apart from that Armie factor, but it's almost like trying to assess whether the appetizer course could have been slightly undercooked while an elephant stampedes over the whole dinner table.

"[70] Joe Morgenstern of The Wall Street Journal wrote that the film "has pizazz and period style in the same way today's big-brand toothpastes have flavor – artificial ingredients give them a taste that's discernible, but too generic to name.