She starred as Maggie Amato on TV Land's Younger, and alongside her husband Gabriele Corcos in the Cooking Channel series Extra Virgin.

[4] Mazar's parents annulled their marriage shortly after she was born,[5] and she spent her early life in the country in upstate New York with her mother.

[5] Mazar left home at 15, and by 16 she was working as a VIP doorperson at the Mudd Club in New York City.

[6] Mazar worked various odd jobs, including selling jewelry at Fiorucci with Linda Ramone and Joey Arias, and later as a dental assistant.

[7] In the early 1980s, Mazar was part of the downtown club scene in New York City, socializing with artists Jean-Michel Basquiat, Keith Haring, and Kenny Scharf.

[8] Mazar has played a number of minor supporting roles in a variety of films, including Sandy, a friend of Henry Hill's mistress in Goodfellas (1990); The Doors (1991); a small role in Spike Lee's Malcolm X (1992); Bullets Over Broadway (1994); and as Spice (of Sugar and Spice, with Drew Barrymore as Sugar) in Batman Forever (1995).

Mazar played the villain Regina, a modern-day Cruella de Vil, in the family film Beethoven's 2nd (1993).

Mazar played Doreen, the Evil Bitch, a crazed pregnant woman who shares a hospital room with Rachel.

[12][13] Also in 2004, she made a cameo appearance in the film Collateral in which she played the passenger while arguing with her boyfriend (Bodhi Elfman) while the main protagonist, Max Durocher (Jamie Foxx), is driving them to their destination.

In 2015, Mazar and her husband started another series on the Cooking Channel entitled Extra Virgin Americana where they travel the U.S., road trip style, with their children and family friend searching for great food.

[citation needed] Between 2020–2021, Mazar and her husband ran a cafe/restaurant called Tuscan Gun in the Windsor Terrace neighborhood of Brooklyn.

They divided their time between Brooklyn and a 15th-century home outside of Florence, Italy, that was given to them as a wedding present by Mazar's in-laws.