In October 2023, she was appointed by Prime Minister Justin Trudeau to replace Irwin Cotler as Canada's Special Envoy on Holocaust Remembrance and Combating Antisemitism.

[3][4][5][6] Lyons owned and managed a hunting and fishing lodge on the Miramichi River and an energy and environment consulting firm prior to becoming involved in government.

[6][7] Despite her roles as Canada's Special Envoy on Holocaust Remembrance and Combating Antisemitism and Canadian Ambassador to Israel, Lyons is not Jewish.

It’s the non-Jews who have to stand up for this battle.”[8] Lyons was appointed Canada's ambassador to Afghanistan by Prime Minister Stephen Harper on 10 July 2013.

[citation needed] In October of 2023, she was appointed by Prime Minister Justin Trudeau as Special Envoy on Holocaust Remembrance and Combatting Antisemitism.