Princess Ramphoei was born in 1834 to Siriwong, Prince Mattayaphithak (son of Rama III and Concubine Sap) and Lady Noi (Mom Noi).

[1] When her father died at only 27 years, her grandfather—the king—took her and her sister Phannarai to the Grand Palace and they were said to be his favourite grandchildren.

[2] In 1853, Ramphoei married her great-uncle Mongkut (who was 30 years her senior) and was raised to a Phra Ong Chao (a higher rank of princess).

When Chulalongkorn was crowned in 1867, she was posthumously given the title Debsirindramataya, the Queen Mother.

Her grandson, Vajiravudh (Rama VI), gave her the name Queen Debsirindra.