Communities along the waterway include Arcadia, Luther, Wellston, Warwick, Sparks, and Welty.
The river is prone to flooding, especially in its lower course where it is bordered by an extensive area of wetlands, temporary and oxbow lakes, and a deciduous bottom land forest, some of which is included in the Deep Fork NWR.
The western portion of the creek's watershed is heavily populated and the name is applied to many retail and residential developments in south Edmond.
In the 1880s, the Deep Fork bottom west of Christian Wells' trading post (present-day Wellston) became a center of Boomer activity.
Soldiers from Fort Reno constantly patrolled the area after Wells hired several of David Payne's lieutenants to work at his store.