Apárt from football, other sports practised at Defensores de Belgrano are boxing, Brazilian jiu-jitsu, kickboxing, karate, and artistic roller skating.

Defensores de Belgrano was founded on 25 May 1906 by a group of young people who wanted to participate in the football leagues of Buenos Aires.

In 1934 two players of the club, Ernesto Belis and Luis Izetta went on to play for the Argentina national team in the 1934 FIFA World Cup held in Italy that year.

In August 2011, the veteran 37-year-old player Ariel Ortega (who had been played for All Boys during the 2010–11 season) was signed by Defensores de Belgrano.

The street's surrounding the Juan Pasquale contain many graffitied wall's and objects in tribute of Defensores de Belgrano, and are the meeting points of many of the club's supporters which begin walking in large groups upon their arrival to the stadium.