From the state line, the route heads east on two-lane undivided Federalsburg Road, passing through agricultural areas with some woods and homes.

East of Cannon, the route passes south of the town limits of Bridgeville, crossing Clear Brook before it comes to an intersection with US 13.

DE 18/DE 404 enters the town of Georgetown and becomes Bridgeville Road, running to the north of the Jack F. Owens Campus of Delaware Technical Community College.

The road intersects US 113 and the western terminus of DE 404 Truck in a commercial area and continues east.

[7] The state highway was completed between Cannon and present-day US 13 and from southeast of Bridgeville east to Lewes by 1924, with the exception of a portion within Georgetown.

The part of present-day DE 18 west of Clarksons Crossroads was under proposal as a state highway by this time also.

[8] A year later, the portions of the route west of Clarksons Crossroads and within Georgetown were upgraded to state highway status.

[12] The portion of road from US 13 east to the current west end of the DE 404 concurrency was completed as a state highway a year later.