Her first studio album appeared in 1956 on Jubilee Records called Melancholy Baby.

Her first RCA Victor studio album was issued in 1960 titled Della.

Four more of Reese's singles made the US Hot 100 chart through 1961 including "Someday (You'll Want Me to Want You)" (1960) and "Won'cha Come Home Bill Bailey" (1961).

At ABC Records, Della Reese Live made the US album chart in 1966.

In 1965, Reese's single "After Loving You" made the US Hot 100 and adult contemporary charts.