Along with holdings of significant blues-related memorabilia, the museum also exhibits and collects art portraying the blues tradition, including works by sculptor Floyd Shaman and photographer Birney Imes.

The shack was restored to structural stability through the intercession of Isaac Tigrett the House of Blues owner and transported from Stovall Plantation on a tour of HoB venues before being returned to Mississippi to the museum and rebuilt inside.

[2] The museum has been visited by many notable artists such as Eric Clapton and Paul Simon.

The Texas-based rock band ZZ Top, especially front man Billy Gibbons, have made this museum their pet project and have raised thousands of dollars in support.

The museum also focuses on educating young people interested in learning to play musical instruments.