Cast members reprising their roles from Animal House included John Vernon (Dean Wormer), Stephen Furst (Flounder), Bruce McGill (D-Day), and James Widdoes (Hoover).

[1] Despite Bluto's absence (it is revealed in the pilot episode that he was expelled from college, and had been drafted into the U.S. Army), the scriptwriters made running references to his character throughout the series.

Because of television Standards and Practices, most of the raunchy humor, sexual references and foul language featured in Animal House did not survive the transition to TV.

In addition, the other two broadcast networks rushed onto the airwaves their own sitcoms that were "inspired" by Animal House: NBC's Brothers and Sisters and CBS' Co-Ed Fever.

However, executive producers Matty Simmons and Ivan Reitman's constant fights with ABC over content led the network to cancel the show after 13 episodes.