[4] Ghrelin can also strongly stimulate somatostatin secretion, thus indirectly inhibiting insulin release.

VIP, vasoactive intestinal peptide, acts positively on δ-cells resulting in more somatostatin being released.

Somatostatin can also indirectly decrease stomach acid production by preventing the release of other hormones, including gastrin, secretin and histamine which effectively slows down the digestive process.

When a person is infected with H. pylori the lower region of the stomach, the antrum, is predominantly inflamed.

[7] In turn, this results in a lower level of somatostatin being secreted and consequently higher release of gastrin and stomach acid.