Depending on the location, it may result in small pustules (pimples) at the base of a hair shaft on inflamed, congested skin.

In the more severe form, hair loss can occur in patches all over the body and might be accompanied by crusting, pain, enlarged lymph nodes, and deep skin infections.

For demodectic mange, properly performed deep skin scrapings generally allow the veterinarian to identify the microscopic mites.

In breeds such as the West Highland White Terrier, relatively minor skin irritation which would otherwise be considered allergy should be carefully scraped because of the predilection of these dogs to demodectic mange.

Dogs with demodicosis show a decrease in plasma copper and zinc levels due to the increased demand for antioxidant activity.

[7] Localized demodectic mange is considered a common puppyhood ailment, with roughly 90% of cases resolving on their own with no treatment.

For more severe generalized cases, Amitraz is a parasiticidal dip that is licensed for use in many countries (the only FDA approved treatment in the USA) for treating canine demodicosis.

Recent results suggest that the isoxazolines afoxolaner and fluralaner, given orally, are effective in treating dogs with generalized demodicosis.

[8][9] Because of the possibility of the immune deficiency being an inherited trait, many veterinarians believe that all puppies with generalized demodex should be spayed or neutered and not reproduce.

Females with generalized demodex should be spayed because the stress of the estrus cycle will often bring on a fresh wave of clinical signs.