The school is located on Louisiana Highway 16, adjacent to Denham Springs Freshman High.

This was the case when flooding devastated the area in 2016, and resulted in students having to travel to nearby Live Oak High School for classes.

[11] Although the school received substantial damage, it was not declared a total loss by the Federal Emergency Management Agency.

There was no work done to prevent future damages from flooding, so the school continued to see issues in 2017 after a heavy rain event.

As of 2019, Denham Springs High School offers 20 AP courses for students to earn college credit.

[17] The Denham Springs High School Wind Ensemble performed at Carnegie Hall in February 2018.

Denham Springs High Lady Jackets' bowling team were crowned state champions for four consecutive years.[when?]

In 1965, Louis “Loodie” Carlisle started a 10-year-run of success, including an undefeated season in 1968 and the state runner up year in 1972.

Playoffs became a regular expectation around Denham Springs, which produced a 10–0 regular season in 1978 and a high school All-American in running back Kelvin Robinson, who went on to play at Tulane and entered the school Hall of Fame in its first year along with his head coach.

The 1986 senior class particular produced three football members for the school's Hall of Fame, among them Glenn Glass, who set a career rushing mark of over 4,000 yards, star defensive back Michael Sceroler, and Ben McDonald, a punter in football who became a baseball star at LSU, Olympic Gold Medalist and the number one Major League Baseball draft pick as a right-handed pitcher with the Baltimore Orioles.