After graduating, Serikov continued his musical career from 1996 to 1998 as a guitarist for the rock band Mongol Shuudan.

While Open Radio was devoted to rock music format, a number of music Serikov's programs gained fame, including "Big Ben Rock" with Sergey Ozon, "Smoke Under Water" with Kirill Nemolyaev [ru] and Alexander Semashko, "Back to the Universe" with Martin Landers, "Bluesology" with Alexey Kalachev and others.

According to the indicators in its second year of broadcasting, Popsa entered the top 15 most popular radio stations in Moscow.

In 2006, Serikov was invited to serve as the general producer of the Energia radio station (broadcasting corporation Prof-Media).

Apple Music helps understand which songs generate the most interest from the audience, Like FM invites performers, so people listen to "a selection of future hits, about which no one knows yet".

[2] Under Serikov's leadership, the radio station also hosts LikeParty—"interactive concerts", the repertoire of which can be influenced by spectators in the hall via a mobile app.

He was tasked to lead the direction of strategic development and content policy of the holding's media assets as well as the promotion and positioning of these brands.

[10] In 2020, Serikov introduced the digital voice assistant Alisa as a radio host on Like FM for several months.

Based on the results of 2012, he was included in the "rating of the best young media managers in Russia" according to PwC and Odgers Berndtson.

In 2020, for the project of integrating the voice assistant Yandex.Alisa as the host of Like FM, Denis Serikov received another Radio Mania award.