On television, she is best known for her roles in the BBC Two crime drama Paula (2017), the ITV miniseries Too Close (2021) and the Disney+ series Andor (2022–).

Born in Wexford and raised in Ennis, County Clare, daughter of an electrician, Gough is the seventh of eleven siblings.

[6] At the National Theatre, London, in September 2015 she presented an "electrifying" performance as a recovering substance user in Duncan Macmillan's People, Places and Things, directed by Jeremy Herrin.

[7] She reprised the role when the production transferred to the Wyndham's Theatre in March 2016, and subsequently won the Olivier Award for Best Actress.

In February 2018, Gough returned to the role of Harper in the Broadway transfer of the National Theatre's production of Angels in America, alongside the majority of the London cast.