[1] In 2006, Rosenthal began her television career as a member of the successful Canal 13 Chilean tween musical series, Amango, playing "Maria Fernanda Mc Gellar" better known as "Feña".

This documentary featured the cast members of "Amango" as they prepared and promoted the series while on a national tour throughout Chile.

Following the success of her participation in Amango, Canal 13 commissioned a spin-off series called El Blog de la Feña.

[6] In April 2012, Rosenthal made her theatre debut as Paz in the Chilean Broadway-style musical, Que Cante La Vida.

[10] At the end of 2011 and for part of the 2012, Rosenthal also participated in the teen television series, El Nuevo, for TVN in Chile.

Although filmed in 2011, the television series, El Nuevo aired special preview on July 4, 2013, for TVN in Chile.

[11] Two ages after, Rosenthal acting in the telenovela of TVN, Matriarcas in the role of Sandra Bravo Peñaloza.

In June 2008, Rosenthal released her first solo single, "No Quiero Escuchar Tu Voz", as part of the promotion for her TV series El Blog de la Feña; the song reached number 8 in Top 100 Chile.

[12] In September 2012, Rosenthal released her third official single, "Dance" featuring the Chilean hip-hop group Crossfire.

[13] In March 2013, Rosenthal announced that her first album as a solo artist was expected to be released in Chile sometime in April.

To promote the single, Rosenthal surprised fans by performing at a metro station in Santiago with a flash mob of 30 dancers.

The controversial music video for "Revolution" was released following an exclusive live acoustic concert, which streamed online for Movistar Chile, on August 18, 2014.

A music video was released on the same day and shows the singer dancing in different places and singing in front of a blue background wearing a flower crown,[24] "Lucha en Equilibrio" and "Encadená".

[26] She followed this with the singles "El Amor no Duele" on August 22,[27] "Ni un fruto" on November 28,[28] and "Tiene Sabor" on February 20, 2020.

[29] In February 2020, Denise won the Silver and Golden Seagull after their presentation in Viña del Mar International Song Festival.