Following the Jyllands-Posten Muhammad cartoons controversy and subsequent attack on the Danish embassy in 2006, relations between the two countries were greatly strained and later suspended.

[1][2][3][4] They waved portraits of Syrian President Bashar al-Assad, leather-bound copies of the Quran, and the flags of Hamas and the Lebanese militant group Hezbollah.

He said "Syria and Iran have taken advantage of the situation because both countries are under international pressure," Rasmussen also said he would "not exclude the possibility" that Syria had also been involved in violent protests in Beirut, Lebanon[8] referring to the fact that similar violence against the Danish Embassy in Beirut occurred the following day after the attacks in Damascus.

[6] A day after the attacks, Syria's foreign ministry issued a statement expressing "its regret over the acts of violence which accompanied the protests."

[2][5] Syrian Foreign Ministry condemned the cartoons as an offence to Muslims and Arabs and demanded the Danish government punish the offending paper.

"[10] Scott McClellan, the White House Press Secretary said “We hold Syria responsible for such violent demonstrations since they do not take place in that country without government knowledge and support,” On the 27 February, Denmark's ambassador to Syria, Ole Egberg Mikkelsen, returned to Damascus, where he had a meeting with the Syrian Deputy Foreign Minister, Ahmad Arnous.

[15] In 2019, Denmark decided to halt renewing temporary protection status of 1,200 individuals, designating government-held areas such as Damascus, Rif Dimashq, Latakia, and Tartus Governorates as safe zones.