In the 1980s, Wolff took Pen-Col Farms international and entered the world market for fresh and frozen bovine embryos.

Wolff received a Master Farmer award in 1994 and was appointed by Governor Ed Rendell as Pennsylvania's Secretary of Agriculture in 2003.

Nicholas spent the first two years of his life in and out of hospitals until receiving a life-saving liver transplant in 1986 at the University of Minnesota.

[4] Camp Victory consists of 14 guest cabins, a dining hall, and a medical shed to address special health needs of campers, among other buildings.

Campers can utilize a nature center, fishing pond, zip line, arts & crafts building, chapel, sports pavilion, archery area, outdoor stage, baseball field, swimming pool, volleyball court, basketball court, game pavilion, wetlands preserve, climbing wall, and wheelchair-accessible tree house during their time at the camp.

After Wolff stepped down from his role as Secretary in 2009, Governor Tom Corbett signed state House Bill 1424 in 2011, making PA Preferred the permanent branding program of agricultural commodities produced in Pennsylvania.

Wolff also founded the "PA Grows" program, which helps agribusinesses in Pennsylvania obtain low-rate financing necessary to begin, continue or expand their operations.

In his announcement, Wolff stated that "When I look at the United States Congress, I don’t see many people that have lived the same kind of life that I have, the same kind of life my neighbors have.”[14] Drawing attention as a qualified candidate and moderate rural Democrat running in a district drawn to favor a Republican, PoliticsPA in October 2017 added this race to their list of vulnerable districts in the 2018 election cycle, noting that "party officials are high on Dennis Wolff, a dairy farmer and former state secretary of agriculture.

"[15] The Democratic Congressional Campaign Committee in November 2017 placed the district on their "battleground" lists for the 2018 election cycle.

[17] Wolff was only one of two Congressional candidates endorsed by the Blue Dogs in Pennsylvania during the 2018 election cycle, the other being Conor Lamb.

On May 15, 2018, Wolff won the Democratic primary for the 9th Congressional District, taking in 41% of the vote, compared to Gary Wegman's 31% and Laura Quick's 28%.

Meuser, who also unsuccessfully ran for Congress in 2008, was plagued then by criticism when he also sought elected office in a district that he did not live in.

Wolff received the support of agricultural equipment manufacturer John Deere and the National Farmers Union.

Wolff in multiple television ads and interviews debunked Meuser's attack, stating publicly that he supported new leadership and would not back Nancy Pelosi.

Meuser, to shock of Republicans and contrary to his campaign messaging, was unable to secure the endorsement of the NRA Political Victory Fund.

[25] Not a single newspaper in the 9th District would endorse Dan Meuser for Congress, despite the significant Republican voter registration advantage.

This was widely seen as a rebuke to Meuser's notoriously short temper, vicious campaign tactics, and Wolff running a final television ad calling for civility in politics.

"[26] The Sunbury Daily Item cited Wolff's moderate views, experience, and emphasis on bipartisanship in their endorsement decision.

[27] Wolff successfully appealed to a broad cross section of the electorate, roughly cutting in half President Trump's 34%+ 2016 margin of victory just two years earlier in the deeply Republican district.