Following a stint in the short-lived hardcore band Step Forward, Lyxzén formed Refused in 1991 with drummer David Sandström, guitarist Pär Hansson, and bassist Jonas Lindgren.

[1][2] In March 2010, there were rumours that Refused would be reuniting after a 12 years hiatus,[3] although Lyxzén dismissed the notion as he and Sandström were busy with the band AC4.

[7] Outside of Refused, Lyxzén has been involved in a number of bands, most notably The (International) Noise Conspiracy, INVSN (previously called The Lost Patrol Band), and Fake Names, the latter a supergroup formed with guitarists Brian Baker (Minor Threat, Bad Religion) and Michael Hampton (Embrace), drummer Matt Schulz (Enon), and bassist Johnny Temple (Girls Against Boys).

In 2011, Lyxzén joined Italian electronic act The Bloody Beetroots for their "Church of Noise" tour as a guest vocalist, and was featured on the act's single of the same name.Lyxzén provided the singing vocals for the character Johnny Silverhand (with Refused portraying the character's band Samurai) in the 2020 video game Cyberpunk 2077.

[11] As a punk rock frontman, Lyxzén's songs are often of a counterculture nature, in line with his socialist politics, although he has explored a variety of topics in his music.