Dennis Herron Murphree (January 6, 1886 – February 9, 1949) was an American politician.

In March 1927, he became Governor of Mississippi after the death of incumbent Henry L. Whitfield.

He served for about ten months until Theodore G. Bilbo, who defeated Murphree in the Democratic Party primary by 10,000 votes, was sworn into office in January 1928.

Defeat has been attributed in part to his having prevented a lynching in Jackson (he mobilized the National Guard and threw up a barbed-wire barricade around the jail).

Paul B. Johnson Sr. in December 1943, Murphree finished out the three weeks left in Johnson's term, serving until the swearing-in of Thomas L. Bailey in January 1944.