Originally sponsored by Kellogg's cereals and Best Foods (Skippy peanut butter), the series was produced by Dariell Productions and Screen Gems.

With CBS seeking to replace the hit show it had lost when it allowed Leave It to Beaver to migrate to ABC, a pilot episode titled "Dennis Goes to the Movies" was filmed in late 1958.

In a 2010 interview, actress Gloria Henry revealed Kearns followed a strict six-week Metrecal diet that may have contributed to his death.

In the fourth and final season, John Wilson purchased the house from his brother, although where George and Martha had moved was never explained.

In 1963, NBC began airing reruns of the series on Saturday mornings for two seasons – the show entered syndication in 1965.

The show was exported to the United Kingdom and shown on the ITV network, with 103 episodes airing in the London region between 1960 and 1966.