Galehouse made his major league debut with the Cleveland Indians in 1934, although did not become a regular pitcher until 1936.

His best seasons came in the 1940s with the St. Louis Browns and Boston Red Sox; he won either 11 or 12 games four times during those years.

He missed the 1945 season due to service in the United States Navy in World War II, at the Great Lakes Naval Training Station, where he was a key fixture on the ball team’s pitching staff and was later discharged on December 15, 1945, returning to the Browns for the 1946 season.

Galehouse started a one-game, winner-take-all playoff for the Red Sox against Cleveland on October 4, 1948 to determine who would win the AL pennant.

Galehouse remained in baseball after his playing career as a scout for both the Red Sox and Indians, as well as the Detroit Tigers, St. Louis Cardinals and San Diego Padres.