The Denrike Building was designed by local architect Appleton P. Clark Jr. and is built with Gothic Revival-style architecture and features Tudor Gothic detailing throughout the building's limestone facade.

[2] Construction of the Denrike Building began in 1925 and was completed in 1926, replacing a Victorian era house that was built in 1884.

Announced in 2022, the Denrike Building's offices are slated to be converted into 85 apartment units with completion in 2025.

[3] The Denrike Building is located within Washington's Financial Historic District.

The building was added to the District of Columbia Inventory of Historic Sites on June 23, 2016[4] and the National Register of Historic Places a week later on June 30.