[2] It flows through an economically important agricultural region, supplies half the drinking water to Ghana's capital city of Accra.

The river ends in an ecologically significant wetland delta[3] on the coast of the Atlantic Ocean.

It has also been identified as an Important Bird Area (IBA) by BirdLife International because it supports significant populations of non-breeding and wintering waterbirds, especially terns, including western reef egrets, spotted redshanks, and little, black, roseate, common, Sandwich and royal terns.

[7] The population density of the Densu Basin is approximately 240 persons per square kilometre.

[8] Part of the Densu River has become a dumping site by some residents in the area, causing water pollution.