Flights are operated with various aircraft, including Embraer ERJ-145 and Fairchild Dornier 328JET regional jets as well as Fairchild Swearingen Metroliner and Embraer EMB-120 Brasilia turboprops under FAR Part 135.

Denver Air Connection has an interline relationship with United Airlines, American Airlines, and Delta Air Lines enabling travelers to fly DAC and connect to these partners without having to collect and recheck baggage.

[2][3] On 15 May 2019, the airline began service to Telluride Regional Airport also operating as Denver Air Connection and using the Fairchild Dornier 328JET.

On June 1, 2019, the airline began its first Essential Air Service (EAS) contract at Alliance Municipal Airport under the Denver Air Connection brand, using the Fairchild Swearingen Metroliner.

Only one of Key Lime Air's Metroliners is set up using the required 9-seat configuration.