The new department is responsible for helping to encourage, develop and manage the UK's scientific, research, and technological outputs.

[2] The department is led by the Secretary of State for Science, Innovation and Technology, supported by a number of junior ministers, and senior civil servants.

[2] Another stated responsibility of the department is to put British public services, including the NHS and schools at the forefront of innovation, championing new ways of working (with an express focus on STEM subjects to improve outcomes for people.

Moreover, DSIT is charged with promoting a diverse research and innovation system that connects discovery to new companies, growth and jobs – including by delivering world-class physical and digital infrastructure.

This is with the professed intention of making the UK the "best place" to start and grow a technology business or to develop and attract "top talent".

DSIT also functions as a means of strengthening international collaboration on science and technology in line with the findings of the 2021 Integrated Review, and to ensure that British researchers are able to continue to work with leading scientists in Europe and around the world.

[6] The Government Chief Scientific Adviser is also attached to the department, and holds the rank of Permanent Secretary.