Derek Jeffries (born 22 March 1951 in Longsight, Manchester, England) is an English former footballer.
In 1973, he transferred to Crystal Palace, where he remained for four years apart from time on loan at Peterborough United and Millwall.
In the summer of 1977, Jeffries joined Chester, who were managed by his former Manchester City teammate Alan Oakes.
In his first season, Jeffries helped them finish fifth in Division Three (now League One), their highest position in the last 60 years.
He left Chester on a free transfer in 1981 and drifted out of professional football, joining Telford United.