Deresse Mekonnen Tsigu (Amharic: ደረሠ መኮንነን; born 20 October 1987) is an Ethiopian middle distance runner, who specializes in the 1500 metres.

Born in Sheno, Oromia Region,[2] his first major international competition was the 2007 World Championships in Osaka where he finished 11th in the heats.

However, the Ethiopian Athletics Federation made an appeal, and the disqualification was reversed, giving Mekonnen the gold medal.

The following year, he became the first Ethiopian to win the Dream Mile and he further improved his national mark in the process, running 3:48.95 minutes.

[10] A stomach problem side-lined him for six months but on his return in January 2011 he broke Bernard Lagat's six-year-long win streak in the Wanamaker Mile at the Millrose Games.