Brown was selected by the Colorado Rapids with the sixth overall pick (first round) of the 2013 MLS SuperDraft on 17 January 2013.

[7] Brown moved from the Tampa Bay Rowdies to D.C. United[8] on 20 June 2017 after the Houston Dynamo traded away their spot in the Major League Soccer allocation order.

[13] On 18 September 2018, it was announced that Brown had again returned to the United States, joining USL side OKC Energy FC.

[14] On 1 January 2020, Brown joined reigning Indian Super League Champions Bengaluru FC on a one-and-a-half-year deal through the end of the 2020–21 season.

On 14 September 2021, NorthEast United and Deshorn Brown have agreed a one-year contract extension for the upcoming season.

Deshorn received his first call-up to Jamaica senior national on 7 October 2013 after scoring what was at the time the second fastest goal in MLS history.